Chronic Bronchitis - Treatment may help asthma sufferers
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Treatment may help asthma sufferers

According to research at Washington University in St. Louis, a two-drug treatment may some day help with restoring healthy breathing in people ill with asthma and chronic bronchitis.

Dr Michael Holtzman and other researchers discovered that some lining cells from the lungs air passages are able to change into another cell type, which leads to the overproduction of mucus in the airways. It was observed in mice and patients suffering from those disorders.

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  The researchers think that further testing of the treatments would take not less than a few years, but they claim that the combination of two drugs finally is able to preclude the pernicious transformation of these cells. It would allow the airways to function properly.

Holtzman declared the discoveries are "pushing the rock a little further up the hill" when it comes to apprehension of airway diseases.

He explained that at present doctors prescribe treatments that ease difficulties with breathing, but, unfortunately, those treatments don't influence on mucus production.

Scientists examined mice with a lung condition similar to asthma and chronic obstructive pulmonary disease, a disease classification which includes chronic bronchitis.

They noticed that the airway lining kept an excess of goblet cells (mucus-producing cells) because of a cup-like shape. The number of goblet cells increased as a result of two cellular mechanisms. One mechanism let the cells live longer because of the cilia, small hairs that help remove remains out of the lungs. The other mechanism provoked those cells to change into goblet cells.

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According to Holtzman, in some people an overabundance of goblet cells is noticed because of viral infections or other factors. It leads to particular breathing disorders. He said the scientists proved that the using a combination of two types of inhibitors can block the excess cells.

One slows down the activity of a epidermal growth factor receptor - a type of a protein which is too active on the airway cells with cilia in mice with the asthma-like condition. If the protein was obstructed, the inhibitor precluded the increase of those cells.


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To know whether bronchitis is contagious or not, you need to know something about the types, causes, and symptoms of the disorder. What is Chronic Bronchitis? In chronic bronchitis, there is inflammation of the mucosal membranes of the bronchial tubes due to infection, a condition that leads to an excess in the production of mucus. This extra mucus disrupts the normal breathing processes by...

Chronic bronchitis is defined as a long term inflammation or swelling of the bronchi. This can result in heightened production of mucus and may be accompanied by other side effects. To be classified as chronic bronchitis, a harsh cough and expectoration (coughing up of mucus) must occur on most days, for no less than three months of the year, for two or more years in a row. This does not...

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Definition It is a type of respiratory disease. It involves inflammation of the mucous membrane in the bronchial passage of the lungs. Coughing spells, breathlessness and thick phlegm accompany this breathing difficulty disease. They are caused by the thickening and swelling of the irritated membrane which closes or narrows down the tiny air passages inside the lungs and makes breathing...

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